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Biochemistry --- Biochimie --- periodicals --- Periodicals --- Périodiques --- Périodiques --- MDBIOCHE MDBIOLOG --- periodicals. --- Biochemistry. --- Biochemistry - Periodicals. --- Biochimie - Périodiques.
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History of human medicine --- History of chemistry --- Cytology --- Life sciences --- Molecular biology --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Biosciences --- Sciences, Life --- Science --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- History of Biology.
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Biochemie --- Biochimie --- Biochimie. --- Biochemistry --- Protéine --- proteins --- Acide aminé --- Amino acids --- Lipide --- Lipids --- Glucide --- Carbohydrates --- Métabolisme énergétique --- Energy metabolism
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For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and antiestrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of publications from which new principles of preventive and therapeutic appli cations of estrogens and antiestrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu ously hallmark results in reproductive endocrinology worldwide.
Estrogen --- Estrogens --- Estrogen Antagonists --- Inhibitors --- Physiological effect --- Therapeutic use. --- Physiological effect. --- pharmacology. --- therapeutic use. --- metabolism. --- Pharmacology. --- Metabolism. --- Biochemistry. --- Cell biology. --- Molecular biology. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Cell Biology. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cell biology --- Cellular biology --- Biology --- Cells --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Composition --- Estrogen replacement therapy --- Oestrogen --- Hormones, Sex --- Anti-estrogenic diet
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In the future' the decade of the 1990s will likely be viewed as a Golden Age for retinoid research. There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of retinoic acid in develop mental processes was first broadly recognized in the late 1980s. Between then and now, our knowledge of retinoid action has evolved from one of a near complete lack of understanding of how retinoids act within cells to one of sophisticated understanding of the molecular processes through which retinoids modulate transcription. In this volume, we have tried to provide a comprehensive update of the present understanding of retinoid actions, with an emphasis on re cent advances. The initial chapters of the volume, or Section A, focus on the physicochemical properties and metabolism of naturally occurring retinoids: - N OY provides an uncommonly encountered view of retinoid effects from the perspective of the physiochemical properties of retinoids. - V AKIANI and BUCK lend a perspective on the biological occurrence and actions of retro- and anhydro-retinoids. Section B considers both the retinoid nuclear receptors and their mechanisms of action as well as synthetic retinoids that have been used exper imentally to provide mechanistic insights into receptor actions and have potential therapeutic use for treating disease: - PIEDRAFITA and PFAHL provide a comprehensive review of retinoid nuclear receptor biochemistry and molecular biology.
Retinoids --- Physiological effect. --- Therapeutic use. --- Therapeutic use --- Physiological effect --- Pharmacology. --- Biochemistry. --- Molecular biology. --- Cancer research. --- Dermatology. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Molecular Medicine. --- Cancer Research. --- Medicine --- Skin --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Diseases --- Composition --- Vitamin A analogs --- Vitamin A congeners --- Vitamin A derivatives --- Carotenoids --- Diterpenes --- Interphotoreceptor retinoid-binding protein
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General biochemistry --- biotechnologie --- Biochemical engineering --- Biotechnology --- bioengineering --- Microbiology --- Biochemistry --- Biomedical Engineering --- Bioengineering --- Biology --- Microbiologie --- Biotechnologie --- Biochimie --- Biologie --- Periodicals. --- Periodicals --- Périodiques --- Biotechnologie. --- 57 --- 579 --- 66.098 --- Biological sciences in general --- Biological processes. Biotechnology --- Engineering --- Life Sciences --- Biotechnology. --- Engineering. --- Life Sciences. --- 66.098 Biological processes. Biotechnology --- 579 Microbiology --- Biomedical Engineering. --- Biochemistry. --- Microbiology. --- biochemie
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The essence of combinatorial chemistry or techniques involving "molecular diversity" is to generate enormous populations of molecules and to exploit appropriate screening techniques to isolate active components contained in these libraries. This idea has been the focus of research both in academia and in the pharmaceutical or biotechnology industry. Its developments go hand in hand with an exploding number of potential drug targets emerging from genomics and proteomics research. When the editors of Current Topics in Microbiology and Immunology encouraged us to assemble the present volume on Combinatorial Chemistry in Biology, we immediately felt that this might prove quite beneficial for the audience of this series. The field of combinatorial chemistry extends over a broad range of disciplines, from synthetic organic chemistry to biochemistry, from material sciences to cell biology. Each of these fields may have its own view on this topic, something which is reflected in a growing number of monographs and "special editions" of jour nals devoted to this issue or aspects thereof. The title of the present volume of Springer-Verlag's series suggests that it also has its own special focus. And, generally speaking, this is not wrong: we would even claim the special focus of this volume is on the immunologically relevant aspects of combinatorial chemistry.
Biologie [Moleculaire ] --- Biologie moléculaire --- Biology [Molecular ] --- Chemie [Combinatorische ] --- Chemistry [Combinatorial ] --- Chimie combinatoire --- Combinatorial chemistry --- Combinatorische chemie --- Moleculaire biologie --- Molecular biochemistry --- Molecular biology --- Molecular biophysics --- Molecular Conformation. --- Biochemistry --- Immunity --- Biochemistry. --- Immunity. --- Immunology. --- Cell biology. --- Biotechnology. --- Cell Biology. --- Chemical engineering --- Genetic engineering --- Cell biology --- Cellular biology --- Biology --- Cells --- Immunobiology --- Life sciences --- Serology --- Combinatorial chemistry. --- Combinatorial organic synthesis --- Combinatorial synthesis (Organic chemistry) --- High-throughput organic synthesis --- High-throughput synthesis (Organic chemistry) --- Multiple parallel synthesis (Organic chemistry) --- Organic compounds --- Pharmaceutical chemistry --- Biochips --- Synthesis
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With contributions by numerous experts.
Acides aminés [Excitation d' ] --- Aminozuren [Opwekkende ] --- Excitation d'acides aminés --- Excitatory amino acids --- Glutamaatreceptoren --- Glutamate [Récepteurs de ] --- Opwekkende aminozuren --- Receptoren [Glutamaat] --- Receptors [Glutamate ] --- Récepteurs de glutamate --- Glutamic acid --- Receptors --- Neurology . --- Pharmacology. --- Neurosciences. --- Molecular biology. --- Human physiology. --- Biochemistry. --- Neurology. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Human Physiology. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Human biology --- Physiology --- Human body --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Medicine --- Neuropsychiatry --- Composition --- Physiological effect --- Diseases --- Receptors, Glutamate. --- Excitatory amino acids. --- Receptors. --- Glutamate --- Umami (Taste) --- Amino acid neurotransmitters
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The question of the existence of other worlds and other living beings has been present in the human quest for knowledge since as far as Epicurus. For centuries this question belonged to the fields of philosophy and theology. The theoretical problem of the formation of the Solar System, and hence of other planetary systems, was tackled only during the 18th century, while the first observational attempts for a detection started less than one hundred years ago. Direct observation of an extra-solar planetary system is an extraordinarily difficult problem: extra-solar planets are at huge distances, are incredibly faint and are overwhelmed by the bright light of their own stars. With virtually no observational insight to test their models, theoreticians have remained for decades in a difficult position to make substantial progress. Yet, the field of stellar formation has provided since the 1980s both the the oretical and observational evidences for the formation of discs at the stage of star birth and for debris materials orbiting the very young stellar systems. It was tempting to consider that these left-overs might indeed later agglomerate into planetary systems more or less similar to ours. Then came observational evidences for planets outside the Solar System.
Astronomy & Astrophysics --- Physical Sciences & Mathematics --- Astrophysics --- Extrasolar planets --- Planets --- Congresses --- Planetology. --- Observations, Astronomical. --- Astronomy—Observations. --- Biochemistry. --- Astrophysics. --- Astronomy, Observations and Techniques. --- Biochemistry, general. --- Astrophysics and Astroparticles. --- Astronomical physics --- Astronomy --- Cosmic physics --- Physics --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Astronomical observations --- Observations, Astronomical --- Planetary sciences --- Planetology --- Composition --- Extrasolar planets. --- Exoplanètes
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Histology. Cytology --- Human biochemistry --- Antigenic determinants --- Galactose --- Galactosyltransferases --- Transferases --- Glycosides --- Monosaccharides --- Antigen determinants --- Antigenic determinant groups --- Determinants, Antigenic --- Epitopes --- Epitypes --- Antigens --- Immunospecificity --- Immunology --- Surgery. --- Biochemistry. --- Surgical transplantation. --- Immunology. --- Biochemistry, general. --- Transplant Surgery. --- Immunobiology --- Life sciences --- Serology --- Medical transplantation --- Organ transplantation --- Organ transplants --- Organs (Anatomy) --- Surgical transplantation --- Tissue transplantation --- Tissues --- Transplant surgery --- Transplantation surgery --- Transplants, Organ --- Surgery --- Preservation of organs, tissues, etc. --- Procurement of organs, tissues, etc. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Surgery, Primitive --- Medicine --- Transplantation --- Composition --- Antigenic determinants.
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